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Related Concept Videos

Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Transient Ischemic Attack l: Introduction01:26

Transient Ischemic Attack l: Introduction

A transient ischemic attack (TIA) is a brief episode of neurological dysfunction caused by a temporary, focal reduction in cerebral blood flow. Although symptoms resemble those of an ischemic stroke, the interruption in perfusion is short-lived and does not cause permanent infarction. TIAs are clinically important because they often serve as early warning events for future stroke.Mechanisms of Transient Cerebral IschemiaTransient cerebral ischemia may arise through several mechanisms. One...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
08:27

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Published on: July 25, 2011

[Celiac disease and ischemic stroke].

B El Moutawakil1, N Chourkani, M Sibai

  • 1Service de neurologie et d'explorations fonctionnelles, CHU Ibn Rochd, quartier des hôpitaux, Casablanca, Maroc. elmoutawakilb@yahoo.fr

Revue Neurologique
|January 16, 2009
PubMed
Summary
This summary is machine-generated.

Celiac disease, an autoimmune disorder, is an uncommon but potential cause of ischemic stroke, even without typical digestive symptoms. Early consideration of celiac disease can identify a treatable cause of stroke.

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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Evaluating Cell Death Signaling by Immunofluorescence in a Rat Model of Ischemic Stroke
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Published on: January 3, 2025

Area of Science:

  • Neurology
  • Gastroenterology
  • Immunology

Background:

  • Celiac disease (CD) presents with diverse neurological symptoms, though its association with ischemic stroke is infrequent and poorly documented.
  • This report details two cases highlighting the link between CD and ischemic stroke.

Observation:

  • Case 1: A patient with a history of transient ischemic strokes experienced an acute ischemic stroke, with investigations revealing celiac disease as the sole identified etiology.
  • Case 2: A patient with diagnosed celiac disease on a gluten-free diet suffered an ischemic stroke; etiological work-up was negative apart from positive celiac serology and iron deficiency anemia.

Findings:

  • The underlying mechanisms linking celiac disease to cerebrovascular events remain debated, with autoimmune central nervous system vasculitis implicated.
  • Tissue transglutaminase, a key auto-antigen in celiac disease, may play a role in endothelial damage, contributing to vascular events.

Implications:

  • Celiac disease should be considered in the etiological investigation of cryptogenic ischemic stroke, especially in younger individuals.
  • Identifying celiac disease as a cause of stroke offers a treatable therapeutic avenue, potentially preventing further vascular events.