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A High Throughput, Multiplexed and Targeted Proteomic CSF Assay to Quantify Neurodegenerative Biomarkers and Apolipoprotein E Isoforms Status
Published on: October 20, 2016
Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease
Jay Jagannathan1, Jie Li, Nicholas Szerlip
1Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892-1414, USA.
Neurosurgery
|January 16, 2009
Summary
Proteomics reveals changing protein expression in neurological diseases. Understanding these patterns is key for neurosurgeons to improve diagnosis and treatment of central nervous system disorders.
Area of Science:
- Proteomics
- Neuroscience
- Molecular Biology
Background:
- Proteins are fundamental cellular components essential for all life.
- The proteome, or the entire set of proteins, is dynamic and linked to neurological disease.
- Proteomics is an emerging field with growing importance in neurosurgery.
Purpose of the Study:
- To review current proteomic technologies.
- To explore the applications of proteomics in central nervous system (CNS) diseases.
Main Methods:
- Selective microdissection for isolating pathological tissues.
- Evaluation of protein expression in various CNS disorders.
Main Results:
- Proteins exhibit differential expression across various disease states.
- Protein expression levels significantly change during disease progression.
- Selective microdissection enables targeted study of disease-related tissues.
Conclusions:
- Understanding nervous system protein expression patterns is crucial for diagnosing and treating neurological diseases.
- Proteomic techniques offer valuable insights for neurosurgical practice.
- Neurosurgeons should familiarize themselves with proteomics for enhanced patient care.
