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Updated: Jun 26, 2026
Ovarian Cancer Detection Using Photoacoustic Flow Cytometry
Published on: January 17, 2020
Novel fluoroimmunoassay for ovarian cancer biomarker CA-125
Davin Sok1, Lisa-Jo A Clarizia, Leslie R Farris
1Biochemistry Program, Department of Chemistry, College of Arts and Sciences, University of Massachusetts, Lowell, MA, 01854, USA.
Abstract:
Cancer antigen 125 (CA-125) is a glycoprotein biomarker that denotes the presence of ovarian and reproductive cancers in women, with serum concentrations of CA-125 greater than 35 U/ml considered indicative of potential malignancies. A fluorescent immunoassay recently developed in our laboratory employing the ALYGNSA antibody-orientation system has been used to measure CA-125 levels. This system displayed significantly increased sensitivity with a detection limit of 1.5 U/ml compared to that of a commercial CA-125 enzyme-linked immunosorbent assay (15 U/ml) This tenfold lower level of detection of the ALYGNSA CA-125 assay should permit better identification and monitoring of ovarian cancer.
