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Related Concept Videos

Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Functional evolution of cyclin-dependent kinases.

John H Doonan1, Georgios Kitsios

  • 1Department of Cell & Developmental Biology, John Innes Centre, Norwich, NR4 7UH, UK. john.doonan@bbsrc.ac.uk

Molecular Biotechnology
|January 16, 2009
PubMed
Summary
This summary is machine-generated.

Cyclin-dependent kinases (CDKs) regulate cell cycles in eukaryotes. This review compares CDK functions across plants, animals, and yeasts, exploring their roles in gene expression and proposing an evolutionary scenario.

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Last Updated: Jun 26, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
12:26

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay

Published on: May 3, 2018

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations
10:54

Studying Proteolysis of Cyclin B at the Single Cell Level in Whole Cell Populations

Published on: September 17, 2012

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET
13:38

Monitoring Kinase and Phosphatase Activities Through the Cell Cycle by Ratiometric FRET

Published on: January 27, 2012

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Cyclin-dependent kinases (CDKs) are crucial regulators of the eukaryotic cell cycle.
  • Emerging evidence suggests CDKs are involved in transcription, translation, and mRNA processing in animal cells.
  • CDK functions in plants, particularly in gene expression regulation, remain largely uncharacterized.

Purpose of the Study:

  • To compare the diverse functions of CDKs in plants, animals, and yeasts.
  • To highlight the emerging roles of CDK phosphorylation in plant gene expression.
  • To propose an alternative evolutionary scenario for the CDK gene family based on functional comparisons.

Main Methods:

  • Comparative analysis of existing literature on CDK functions across different species.
  • Focus on biological processes regulated by various CDK members.
  • Synthesis of information to propose an evolutionary hypothesis.

Main Results:

  • CDKs exhibit conserved roles in cell cycle regulation across eukaryotes.
  • Significant differences exist in the non-cell cycle-related functions of CDKs among plants, animals, and yeasts.
  • Plant CDKs show a growing involvement in gene expression regulation, distinct from their established cell cycle roles.

Conclusions:

  • CDK functions extend beyond cell cycle control, encompassing diverse cellular processes.
  • Comparative studies reveal species-specific adaptations and conserved roles of CDKs.
  • Further research is needed to fully elucidate the evolutionary trajectory and functional diversification of the CDK gene family.