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Updated: Jun 26, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
[Pharmacologic treatment of atrial fibrillation]
Abstract:
Atrial fibrillation is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation with consequent deterioration of atrial mechanical function. It is a common arrhythmia that presents various treatment options. Pharmacologic therapy is used to maintain sinus rhythm, to control the ventricular response, or to convert atrial fibrillation to sinus rhythm and prevention of thromboembolism. Cardioversion shocks are applied through surface or intrathoracic electrodes to convert atrial fibrillation to sinus rhythm. The tendency for recurrence of atrial fibrillation is high. Treatment with antiarrhythmic drugs has decreased its recurrence. Drugs that slow conduction through the AV node (such as digoxin, beta blockers and calcium channel blockers) have been used as adjuvants to therapy for the prevention of atrial fibrillation. Drugs used for the prevention of atrial fibrillation are antiarrhythmic drugs of class IA and C, and type III. Drug combination acting through different electrophysiological channels and mechanisms may prove beneficial in the prevention of atrial fibrillation.
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