[Persistent ethanol drinking increases liver injury induced by trinitrotoluene exposure: an in-plant case-control...

On the basis of a general survey conducted in a munitions plant, a case-control study was made on the various risk factors of liver damage induced by trinitrotoluene (TNT) exposure in the plant. The result of analysis showed that two factors the amount of ethanol drunk on each occasion and the frequency of drinking every week had a dose response relationship with their OR of occupational TNT Liver damage, but there was no connection between smoking and occupational TNT liver damage and no interaction between drinking and smoking on occupational TNT liver damage. The above results have revealed that exposure to TNT and with a long history of heavy drinking, have a greater risk of suffering from chronic liver impairment than non-drinking TNT exposure workers.