Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Experiences with Last Aid Courses as Tool for Public Palliative Care Education in Brazil.

Nursing reports (Pavia, Italy)·2025
Same author

The Patterns of P53, E-Cadherin, β-Catenin, CXCR4 and Podoplanin Expression in Oral Squamous Cell Carcinoma Suggests a Hybrid Invasion Model: an Immunohistochemical Study on Tissue Microarrays.

Head and neck pathology·2025
Same author

Enhanced mitochondrial function in B cells from elderly type-2 diabetes mellitus patients supports intrinsic inflammation.

Frontiers in aging·2024
Same author

Adipocyte-derived inflammatory molecules induce senescent B cells through metabolic pathways.

Obesity (Silver Spring, Md.)·2024
Same author

Angiotensin Converting Enzyme 1 Expression in the Leukocytes of Adults Aged 64 to 67 Years.

JMIRx med·2023
Same author

Mini-review: Angiotensin- converting enzyme 1 (ACE1) and the impact for diseases such as Alzheimer's disease, sarcopenia, cancer, and COVID-19.

Frontiers in aging·2023

Related Experiment Video

Updated: Jun 26, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

FTY720 and lung tumor development.

Natália Regina Antunes Salinas1, Celina Tizuko Fujiyama Oshima, Patrícia Maluf Cury

  • 1Division of Immunology, UNIFESP-Federal University of São Paulo, R. Botucatu 862, São Paulo, Brazil.

International Immunopharmacology
|January 17, 2009
PubMed
Summary

The timing of FTY720 administration impacts its cancer-preventing effects. Early FTY720 treatment after lung tumor induction in mice showed potential benefits in reducing cancer development.

Related Experiment Videos

Last Updated: Jun 26, 2026

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
09:02

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment

Published on: June 28, 2018

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • FTY720 demonstrates cancer-preventive properties in preclinical models.
  • The influence of drug administration timing on FTY720's efficacy remains uninvestigated.

Purpose of the Study:

  • To investigate the time-dependent effects of FTY720 on lung tumor development in a mouse model.
  • To evaluate if early administration of FTY720 influences cancer progression.

Main Methods:

  • Lung adenoma was induced in BALB/c mice using urethane.
  • FTY720 was administered at different time points post-urethane injection.
  • Leukocyte counts, spleen lymphocyte counts, and lung histology, PCNA, and VEGF expression were analyzed.

Main Results:

  • Higher lung nodule counts were observed in untreated mice and those treated 8 weeks after urethane.
  • Early FTY720 treatment (G2) showed a decrease in PCNA and VEGF staining.
  • Groups G1 and G4 exhibited lower splenocyte and neutrophil counts.

Conclusions:

  • The therapeutic benefits of FTY720 are significantly time-dependent.
  • Early administration of FTY720 post-lung tumor induction may inhibit cancer development.
  • Late administration of FTY720 does not appear to confer protective effects.