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Non-Canonical Wnt Signaling Pathways

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

Canonical Wnt Signaling Pathway

Canonical Wnt Signaling Pathway

The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which results in tumor...

Canonical Wnt Signaling Pathway

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Microtubules in Signaling

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...

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Related Experiment Video

Updated: Jun 26, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Ciliary function and Wnt signal modulation.

Jantje M Gerdes¹, Nicholas Katsanis

¹McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Current Topics in Developmental Biology

|January 17, 2009

Summary

The cilium regulates paracrine signal transduction, with basal body and ciliary proteins linking to Wnt signaling. Aberrant Wnt signaling may drive ciliopathy phenotypes, potentially due to loss of noncanonical Wnt signaling.

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Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

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Last Updated: Jun 26, 2026

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea

Published on: February 21, 2016

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Modeling Paracrine Noncanonical Wnt Signaling In Vitro

Published on: December 10, 2021

Area of Science:

Cell Biology
Developmental Biology
Genetics

Background:

Cilia are increasingly recognized as key regulators of paracrine signal transduction.
Evolutionary expansion of ciliated organisms highlights the cilium's regulatory role.
Emerging evidence links basal body and ciliary proteins to Wnt signaling pathways.

Purpose of the Study:

To evaluate the evidence connecting basal bodies and cilia to Wnt signaling regulation.
To explore the roles of Wnt signaling in ciliogenesis.
To discuss the contribution of aberrant Wnt signaling to ciliopathies.

Main Methods:

Literature review and evidence synthesis.
Analysis of existing data on ciliary and basal body proteins.
Comparative analysis of Wnt signaling in ciliopathies.

Main Results:

The cilium acts as a crucial regulator of paracrine signaling.
Proteins within basal bodies and cilia are implicated in both canonical and noncanonical Wnt signaling.
Aberrant Wnt signaling, particularly loss of noncanonical pathways, is associated with ciliopathy phenotypes.

Conclusions:

The cilium is a central hub for Wnt signal transduction.
Wnt signaling plays a significant role in ciliogenesis.
Loss of noncanonical Wnt signaling may be a key driver of ciliopathy pathogenesis.