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Updated: Jun 26, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Haplotype analysis of the CYP8A1 gene associated with myocardial infarction
Xiang Xie1, Yi-Tong Ma, Zhen-Yan Fu
1Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Objective:
The aim of this study was to assess the association between the human CYP8A1 gene and myocardial infarction (MI) in Chinese people.
Methods:
210 MI patients and 206 age-matched controls were genotyped and constructed haplotypes for 3 SNPs [3982C>T (rs5602), C1117A (rs5629), C251T (rs454-98106)] of the human CYP8A1 gene.
Results:
The CC genotype of rs5629 was more frequently in MI patients than in control subjects (P = .030). The frequency of the A-C-T haplotype was significantly higher in MI patients than in control subjects (P =.001). The frequency of the C-T-T haplotype was significantly lower in MI patients than in control subjects (P= .011).
Conclusions:
The present results indicate that MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people.
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