Related Experiment Video

Updated: Jun 26, 2026

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
09:42

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis

Published on: June 26, 2019

Modulation of g protein signaling normalizes tumor vessels

Mitali Manzur1, Juliana Hamzah, Ruth Ganss

  • 1Western Australian Institute for Medical Research, The University of Western Australia Centre for Medical Research, Perth, Western Australia, Australia.

Cancer Research
|January 17, 2009
PubMed

Insights

Regulators of G protein signaling 5 (RGS5) influence tumor blood vessel development. Removing RGS5 normalizes tumor vessels, improving blood flow and enhancing anti-tumor immunotherapy effectiveness.

Area of Science:

  • Molecular biology
  • Cancer research
  • Immunology

Background:

  • G protein-coupled biological processes are implicated in numerous human diseases.
  • Regulators of G protein signaling (RGS) are crucial accessory molecules for fine-tuning these processes.
  • RGS5, a marker for tumor-resident pericytes, is vital in vascular maturation and remodeling during cancer development.

Purpose of the Study:

  • To investigate the role of RGS5 in tumor vascularization and its impact on anti-tumor immunity.
  • To explore the therapeutic potential of targeting RGS5 for improving cancer treatments.

Main Methods:

  • Analysis of tumor morphology and blood flow in RGS5-deficient models.
  • Assessment of lymphocyte infiltration and response to immunotherapy in RGS5-deficient tumors.

Main Results:

  • Tumors in RGS5-deficient backgrounds exhibit normalized vessel morphology.
  • RGS5 deficiency leads to improved blood flow within tumors.
  • These vascular changes significantly enhance lymphocyte access and the efficacy of anti-tumor immunotherapy.

Conclusions:

  • RGS5 plays a critical role in regulating tumor angiogenesis and vascular remodeling.
  • Targeting RGS5 presents a promising strategy for enhancing the effectiveness of anti-cancer therapies, particularly immunotherapy.

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