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Related Experiment Video

Updated: Jul 28, 2026

Catheterization of Intestinal Loops in Ruminants
17:15

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Published on: June 11, 2009

Endoscopic retrograde sphincterotomy in swine.

C F Gholson1, J M Provenza, J T Doyle

  • 1Department of Medicine, Louisiana State University School of Medicine, Shreveport.

Digestive Diseases and Sciences
|October 1, 1991
PubMed
Summary

Pigs tolerated endoscopic retrograde sphincterotomy, showing prompt recovery and no complications. This study validates pigs as a model for endoscopic sphincterotomy research, though training use is limited.

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Area of Science:

  • Gastroenterology
  • Surgical Research
  • Comparative Medicine

Background:

  • Endoscopic retrograde sphincterotomy (ERS) is a key therapeutic endoscopic procedure.
  • Establishing reliable animal models is crucial for advancing endoscopic techniques and research.
  • Pigs offer physiological similarities to humans, making them potential models for gastrointestinal procedures.

Purpose of the Study:

  • To evaluate the feasibility and safety of performing endoscopic retrograde sphincterotomy (ERS) in a porcine model.
  • To assess the immediate and short-term outcomes of ERS in pigs.
  • To determine the suitability of pigs as an experimental model for ERS research.

Main Methods:

  • Four pigs (3-4 months old) underwent endoscopic retrograde sphincterotomy using standard human endoscopic equipment.
  • Sphincterotomies were 1 cm in length.
  • Animals were monitored for recovery, gastrointestinal function, weight gain, and underwent necropsy at different time points (immediate and one week post-procedure).

Main Results:

  • The endoscopic retrograde sphincterotomy procedure was well-tolerated in all four pigs.
  • Animals exhibited prompt recovery, spontaneous restoration of gastrointestinal function, and weight gain.
  • Autopsy revealed no complications such as perforation or significant adverse effects in pigs sacrificed at one week or immediately post-procedure.

Conclusions:

  • The pig serves as a valid experimental model for endoscopic retrograde sphincterotomy.
  • The procedure is safe and well-tolerated in the porcine model, with no observed complications.
  • While technically and anatomically different from humans, limiting its use in training, the pig model holds potential for future research in endoscopic sphincterotomy.