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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...

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Updated: Jun 26, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

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Published on: June 14, 2024

Systemic low-grade inflammation does not decrease skeletal muscle mass and protein synthesis in old rats.

G Mayot1, D Breuille, A R Jarret

  • 1INRA, UMR 1019 Nutrition Humaine, F-63122 Saint-Genes-Champanelle, Univ Clermont 1, UFR Medecine, F-63001 Clermont-Ferrand, France.

Journal of Musculoskeletal & Neuronal Interactions
|January 17, 2009
PubMed
Summary
This summary is machine-generated.

Persistent low-grade inflammation in old rats did not reduce skeletal muscle mass or protein synthesis. This suggests age-associated inflammation and sarcopenia may develop independently.

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Area of Science:

  • Gerontology
  • Physiology
  • Immunology

Background:

  • Age-associated low-grade systemic inflammation is a potential contributor to sarcopenia.
  • Sarcopenia, the loss of skeletal muscle mass and function, is a common aging-related condition.

Purpose of the Study:

  • To investigate the relationship between persistent low-grade inflammation and skeletal muscle mass and protein synthesis in aged rats.
  • To determine if age-associated inflammation directly impacts muscle health.

Main Methods:

  • Comparison of male 24-month-old Wistar rats with (LGI group) and without (C group) persistent low-grade inflammation.
  • Quantification of tissue protein synthesis rates using the L-[1-(13)C]-valine flooding dose method.
  • Measurement of body weight, gastrocnemius muscle, spleen, liver, and small intestine weights.

Main Results:

  • No significant differences in body weight, gastrocnemius muscle, or spleen weights between LGI and C groups.
  • Increased liver and small intestine weights in the LGI group compared to the C group.
  • Skeletal muscle protein synthesis rates were not significantly different, but liver protein synthesis was higher in the LGI group.

Conclusions:

  • Persistent low-grade inflammation in aged rats does not lead to sarcopenia.
  • Age-associated low-grade systemic inflammation appears to occur independently of sarcopenia.
  • The findings suggest distinct pathways for inflammation and muscle aging.