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Updated: Jun 26, 2026
08:32
Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
Published on: March 16, 2017
Endothelial nitric oxide synthase: from structure to function in one aspartic substitution.
1Department of Medicine, Renal Research Institute, New York Medical College, Valhalla, New York 10595, USA. michael_goligorsky@nymc.edu
Kidney International
|January 17, 2009
Summary
The G894T polymorphism in endothelial nitric oxide synthase (eNOS) may impair kidney function. Healthy individuals with the GG genotype showed improved renal hemodynamics with L-arginine, unlike GT/TT genotypes.
Area of Science:
- Cardiovascular Science
- Nephrology
- Genetics
Background:
- Investigating the functional impact of the endothelial nitric oxide synthase (eNOS) G894T polymorphism.
- Utilizing L-arginine infusion to assess renal hemodynamic responses in healthy subjects.
Discussion:
- Comparing renal blood flow and glomerular filtration rate changes between eNOS G894T genotypes (GG vs. GT/TT).
- Exploring potential mechanisms: impaired eNOS function in GT/TT or enhanced responsiveness in GG individuals.
Key Insights:
- L-arginine infusion significantly improved effective plasma flow and glomerular filtration rate in subjects with the GG genotype.
- These beneficial hemodynamic responses to L-arginine were notably blunted in subjects with the GT or TT genotypes.
- The findings suggest a genotype-dependent effect of eNOS on renal hemodynamics.
Outlook:
- Further research is needed to elucidate the precise mechanisms underlying the observed differences in eNOS responsiveness.
- Investigating the long-term clinical implications of the eNOS G894T polymorphism in renal health.
- Exploring potential therapeutic strategies targeting eNOS pathways for kidney protection.
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