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Updated: Jun 26, 2026

Arbovirus Infections As Screening Tools for the Identification of Viral Immunomodulators and Host Antiviral Factors
Published on: September 13, 2018
Apoptosis in animal models of virus-induced disease
Penny Clarke1, Kenneth L Tyler
1Department of Neurology, University of Colorado, Denver Health Sciences Programs, Anschutz Medical Campus, Aurora, Colorado 80045, USA. Penny.Clarke@uchsc.edu
Abstract:
Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.
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