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Updated: Jun 26, 2026

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In Vitro Assay to Study Tumor-macrophage Interaction
Published on: August 1, 2019
Macrophage inhibitory cytokine-1: a new player in melanoma development
Toshiharu Yamashita1, Akihiro Yoneta, Tokimasa Hida
1Department of Dermatology, Sapporo Medical University, Sapporo, Japan. yamasita@sapmed.ac.jp
The Journal of Investigative Dermatology
|January 17, 2009
Abstract:
Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. Although it has been reported to exhibit both tumorigenic and antitumorigenic activities, Boyle et al. report in this issue that MIC-1 expression was correlated with the tumorigenicity of melanoma cells. The elucidation of signaling pathways around MIC-1 might contribute to prospective targeting therapy for melanoma.

