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Published on: November 17, 2018
[Advances in sterol 14alpha-demethylase (CYP51)]
Jiaoyan Yang1, Mingjun Liao, Shao Yang
1College of Life Sciences, Central China Normal University, Wuhan 430079, China.
Abstract:
Sterol 14alpha-demethylase (CYP51), the most widely distributed member of the P450 superfamily, is the key enzyme in sterol biosynthesis pathway. CYP51 is not only an important model for fundamental P450 structure/function studies, but also an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. This article reviewed the research advances in CYP51 at various aspects, including sequence characteristics, physiological roles, catalytic properties in vitro, protein structure, structure-function relationships and inhibition of CYP51. The problems remained in current research and designations of CYP51 inhibitors are also discussed.
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