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[Stability of physical state on compound hawthorn dropping pills]
Wei Zhang1, Hong-Yan Chen, Jian-Lan Jiang
1School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Objective:
To evaluate the stability of physical state with accelerate test and dropping in process before and after on compound hawthorn dropping pills.
Method:
Scanning electron microscope, TG-DTA, FT-IR and XRD were used.
Result:
The active components presented amorphous, tiny crystal and molecular state in dropping pills, and it had no obvious reaction between PEG 4000 and active components. With time prolonging, a little of active components changed from amorphous state to tiny crystal or molecular state.
Conclusion:
Solid dispersion improved the stability and dissolution of compound hawthorn dropping pills.
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