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Related Experiment Video

Updated: Jun 26, 2026

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Culturing and Electrophysiology of Cells on NRCC Patch-clamp Chips

Published on: February 7, 2012

The Chiptip: a novel tool for automated patch clamp.

Albrecht Lepple-Wienhues¹, Dirck Lassen, Alexander Hümmer

¹Flyion GmbH, Waldhäuserstr. 64, D-72076 Tübingen, Germany. info@flyion.com

Combinatorial Chemistry & High Throughput Screening

|January 20, 2009

Summary

A new all-glass Chiptip pipette enhances automated patch clamp studies for ion channels. This innovation reduces cell and drug volume requirements, enabling efficient screening of small cells and organelles.

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Area of Science:

Biophysics
Cell Biology
Pharmacology

Background:

Automated patch clamp electrophysiology is crucial for ion channel research.
High-throughput screening requires efficient and cost-effective methods.
Current methods can be limited by cell numbers and reagent volumes.

Purpose of the Study:

To develop an improved apparatus for automated patch clamp measurements.
To reduce the number of cells and drug volumes required for ion channel screening.
To enhance the study of small cellular structures and microorganisms.

Main Methods:

Development of an all-glass Chiptip pipette.
Integration with existing Flip-the-Tip technology.
Optimization of drug addition protocols for low-volume screening.

Main Results:

The Chiptip pipette facilitates automated patch clamp measurements.
A single measurement requires fewer than 50 cells.
Drug screening volumes can be reduced to as low as 1 microliter.

Conclusions:

The developed apparatus enables efficient ion channel studies.
The technology is suitable for small cells, subcellular organelles, and bacteria.
This advancement supports cost-effective and high-throughput ion channel screening.