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Published on: April 18, 2019

Doripenem: a new addition to the carbapenem class of antimicrobials

Jason J Schafer1, Debra A Goff, Julie E Mangino

  • 1UPMC St. Margaret Hospital Department of Pharmacy, Pittsburgh, Pennsylvania 15215, USA. schaferjj@upmc.edu

Recent Patents on Anti-Infective Drug Discovery
|January 20, 2009
PubMed

Insights

Doripenem is a new carbapenem antibiotic effective against drug-resistant bacteria. It shows potent activity and may be less likely to induce resistance than other carbapenems.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Doripenem is a novel antimicrobial agent within the carbapenem class.
  • It exhibits broad-spectrum activity against Gram-positive, Gram-negative, and anaerobic bacteria.

Purpose of the Study:

  • To introduce Doripenem (DPM) and discuss its potential applications.
  • To review its role in treating infections caused by multi-drug resistant Gram-negative bacteria.
  • To examine recent patents concerning carbapenem antimicrobials.

Main Methods:

  • In vitro susceptibility testing was performed.
  • Literature review of Doripenem's efficacy and resistance profiles.
  • Analysis of recent carbapenem-related patents.

Main Results:

  • Doripenem demonstrates potent in vitro activity against many drug-resistant Gram-negative pathogens.
  • It shows efficacy against strains resistant to imipenem and meropenem.
  • Doripenem may induce resistance less frequently in certain pathogens compared to other carbapenems.

Conclusions:

  • Doripenem presents a promising therapeutic option for infections involving multi-drug resistant Gram-negative bacteria.
  • Its unique activity profile warrants further investigation for clinical application.
  • Ongoing research and patent activity highlight the evolving landscape of carbapenem antibiotics.

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