Related Experiment Video

Updated: Jun 26, 2026

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions
08:12

Calculating Heart Rate Variability from ECG Data from Youth with Cerebral Palsy During Active Video Game Sessions

Published on: June 5, 2019

Heart rate variability analysis at coronary artery disease and angina pectoris

Tatyana Mironova1, Vladimir Mironov, Vladimir Antufiev

  • 1Chelyabinsk State Medical Academy, Chelyabinsk 454091, Russia. micor_mail@mail.ru

Recent Patents on Cardiovascular Drug Discovery
|January 20, 2009
PubMed

Insights

High-resolution heart rate variability (HRV) analysis reveals autonomic and humoral disregulation in coronary artery disease (CAD) and angina pectoris (AP). This method aids in diagnosing, managing, and predicting outcomes for patients with these conditions.

Area of Science:

  • Cardiology
  • Medical Technology
  • Physiology

Background:

  • Coronary artery disease (CAD) and angina pectoris (AP) significantly impact patient health.
  • Standard cardiological methods may not fully capture the complexities of these conditions.
  • Understanding autonomic and humoral influences on cardiac function is crucial for effective management.

Purpose of the Study:

  • To present findings from special examinations and prospective observations of CAD and AP patients.
  • To evaluate autonomic and humoral-metabolic influences on heart sinus node activity.
  • To explore the diagnostic and prognostic value of high-resolution heart rate variability (HRV) analysis.

Main Methods:

  • Utilized high-resolution rhythmocardiography and a specialized apparatus-program complex.
  • Registered and analyzed heart rate variability (HRV) in 273 patients with CAD and AP.
  • Employed inclusion-exclusion criteria for patient selection.

Main Results:

  • High-resolution HRV analysis identified autonomic and humoral disregulation associated with ischemic heart disease.
  • Angina pectoris episodes correlated with HRV stabilization during ischemic events.
  • HRV patterns allowed for characterization of AP, prediction of complications (e.g., acute coronary syndrome), risk assessment, and evaluation of drug efficacy (e.g., nitroglycerin).

Conclusions:

  • High-resolution HRV analysis is an informative and promising method for diagnosing and managing CAD and AP.
  • Prospective observations using HRV analysis helped establish an "ischemic cascade" in HRV symptoms.
  • This technique offers potential for personalized risk stratification and treatment monitoring in cardiovascular disease.

More Related Videos

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis18:11

A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

Published on: December 28, 2012

Related Concept Videos

Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Electrocardiogram01:29

Electrocardiogram

An electrocardiogram (ECG or EKG) is a critical diagnostic tool that records the electrical signals produced by the heart during each heartbeat. This recording is achieved through electrodes placed strategically on the arms, legs, and chest. The electrocardiograph amplifies these signals and produces 12 distinct tracings, offering a comprehensive understanding of the heart's electrical activity.
Three major waveforms are present in a typical ECG recording: the P wave, the QRS complex, and the T...
Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...