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Pathogenesis of odontogenic cysts: an update
1Department of Dental Surgery, University of Nairobi.
East African Medical Journal
|April 1, 1991
Summary
This review explores odontogenic cysts, including keratocysts, follicular cysts, and radicular cysts. Understanding their cellular and molecular mechanisms, like bone resorption mediators, is key to better management.
Area of Science:
- Oral Pathology
- Developmental Biology
- Molecular Medicine
Background:
- Odontogenic cysts are diverse lesions with varying origins.
- Radicular cysts, linked to non-vital teeth, arise from cell rests of Malassez.
- Bone resorption is crucial for the expansion of these bony lesions.
Purpose of the Study:
- To review the origin, classification, and pathogenesis of odontogenic cysts.
- To present current concepts on the role of cellular and chemical mediators in cyst initiation and growth.
- To highlight the significance of understanding molecular mechanisms for improved management.
Main Methods:
- Literature review of odontogenic cyst pathogenesis.
- Discussion of cellular and molecular mediators involved in bone resorption.
- Synthesis of evidence on enzymes, cytokines, and metabolites.
Main Results:
- Keratocysts and follicular cysts originate from dental lamina and follicle remnants.
- Radicular cysts develop from inflamed granulomata at tooth apices.
- Enzymes, cytokines (e.g., interleukin-1), and prostaglandins play roles in cyst growth.
Conclusions:
- Understanding the cellular and molecular behavior of odontogenic cysts is essential.
- Knowledge of these mechanisms can lead to more effective treatment strategies.
- Further research into tissue-degrading pathways may improve cyst management.
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