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Updated: Jun 26, 2026
04:39
A Neonatal Rodent Model of Retroorbital Vein Injection
Published on: February 23, 2024
[Neonatal renal venous thrombosis in 2008]
Summary
Neonatal renal venous thromboses (NRVT) are rare but serious. Reviews show increased incidence in premature infants, with male predominance and left kidney involvement, often linked to thrombophilia.
Area of Science:
- Pediatric Nephrology
- Neonatal Medicine
- Hematology
Background:
- Venous thromboses are uncommon in children, with neonatal renal venous thromboses (NRVT) being the primary form in newborns.
- Recent reviews highlight evolving epidemiological features of NRVT over the past 15 years.
Purpose of the Study:
- To synthesize recent reviews on neonatal renal venous thromboses (NRVT).
- To update understanding of NRVT epidemiology, diagnosis, and management.
Main Methods:
- Systematic review and synthesis of recent literature on NRVT published within the last 15 years.
- Analysis of epidemiological data, diagnostic approaches, and treatment recommendations.
Main Results:
- Higher male prevalence, predominant left kidney vein involvement, and increasing incidence in premature newborns.
- High thrombophilia rates in screened newborns; typical presentation modified by new features.
- Abdominal Doppler ultrasound is key for diagnosis, with mandatory transfontanellar ultrasound to rule out cerebral hemorrhage.
Conclusions:
- Prophylactic heparin is recommended for most NRVT cases to prevent extension.
- Fibrinolysis is reserved for severe bilateral thrombosis with systemic effects.
- Despite advances, significant long-term sequelae (kidney atrophy, insufficiency, hypertension) and relapses remain common; systematic pediatric nephrology follow-up is crucial.
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