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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Increased cardiovascular risk associated with reduced kidney function

Timothy P Ryan1, Susan G Fisher, Jessica L Elder

  • 1Division of Epidemiology, Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA. givansati@yahoo.com

American Journal of Nephrology
|January 20, 2009
PubMed

Insights

Individuals with chronic kidney disease (CKD) face increasing cardiovascular mortality risk as kidney function declines. Early CKD identification and management are crucial for reducing this risk.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is linked to high cardiovascular mortality risk.
  • Specific risks associated with varying glomerular filtration rates (GFRs) in CKD patients remain unclear.

Purpose of the Study:

  • To investigate the relationship between kidney function levels and cardiovascular mortality risk.
  • To analyze this association in a diverse patient population.

Main Methods:

  • A nonconcurrent cohort study involving 34,982 ambulatory patients.
  • Kidney function, measured as estimated GFR (eGFR), was analyzed as a time-dependent variable.
  • Adjusted hazard ratios for cardiovascular mortality were calculated for different eGFR ranges.

Main Results:

  • A graded increase in cardiovascular mortality risk was observed with decreasing eGFR.
  • Patients with eGFR 30-44 had a 1.77-fold increased risk; eGFR 15-29 had a 3.75-fold increased risk; and eGFR <15 had a 3.83-fold increased risk.
  • A marked increase in risk was noted for eGFR <45 ml/min/1.73 m(2).

Conclusions:

  • Cardiovascular mortality risk significantly increases as kidney function declines, particularly with eGFR <45 ml/min/1.73 m(2).
  • The widespread availability of eGFR has had minimal impact on mitigating cardiovascular risk in CKD patients.
  • Early detection and management of CKD are vital public health priorities to reduce cardiovascular mortality.
Abstract

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