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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
DNA Microarrays02:34

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Related Experiment Video

Updated: Jun 26, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
07:35

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

Published on: October 11, 2018

[Biomarker].

Takayuki Ueno1, Masakazu Toi

  • 1Dept. of Surgery, Kyoto University Graduate School of Medicine, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 20, 2009
PubMed
Summary
This summary is machine-generated.

Biomarkers are crucial for breast cancer management, aiding diagnosis and treatment selection. Understanding these molecular indicators is key to advancing personalized medicine and improving patient outcomes.

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Last Updated: Jun 26, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
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Published on: October 11, 2018

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Context:

  • Biomarkers are integral to breast cancer management, influencing diagnosis, treatment selection, and monitoring.
  • Current strategies rely on hormone receptor and HER2 status, but research is expanding to novel biomarkers.
  • Gene expression profiles and circulating cells are emerging as critical tools.

Purpose:

  • To highlight the pivotal role of biomarkers in breast cancer.
  • To discuss the evolving landscape of breast cancer biomarkers beyond traditional markers.
  • To emphasize the necessity of biomarker comprehension for personalized medicine.

Summary:

  • Biomarkers are essential for breast cancer diagnosis, treatment selection, and monitoring.
  • Novel biomarkers, including gene expression profiles and circulating tumor/endothelial cells, are being investigated to predict treatment efficacy.
  • Understanding these diverse biomarkers is fundamental for the advancement of personalized breast cancer care.

Impact:

  • Facilitates more accurate breast cancer diagnosis and prognosis.
  • Enables tailored treatment selection, optimizing therapeutic efficacy.
  • Supports continuous monitoring of treatment response and disease progression.
  • Drives the development of personalized medicine approaches in oncology.