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Updated: Jun 26, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration
Published on: March 17, 2014
Laminar and compartmental regulation of dendritic growth in mature cortex
David K Chow1, Matthias Groszer, Mochtar Pribadi
1Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles Young Drive, South, Los Angeles, California 90095-1761, USA.
Abstract:
Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
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