Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Obesity

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...

Coronary Artery Disease I: Introduction

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...

Hypertension II: Pathophysiology

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Platelet rescue by macrophage depletion in obese ADAMTS-13-deficient mice at risk of thrombotic thrombocytopenic purpura.

Journal of thrombosis and haemostasis : JTH·2017

Same author

Reproducibility of studies with genetically modified mice.

Journal of thrombosis and haemostasis : JTH·2017

Same author

Macrophage elastase (MMP-12) in expanding murine adipose tissue.

Biochimica et biophysica acta·2013

Same author

The hyperfibrinolytic state of mice with combined thrombin-activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 gene deficiency is critically dependent on TAFI deficiency.

Journal of thrombosis and haemostasis : JTH·2012

Same author

Unveiling an exceptional zymogen: the single-chain form of tPA is a selective activator of NMDA receptor-dependent signaling and neurotoxicity.

Cell death and differentiation·2012

Same author

Effect of ageing on the murine venous circulation.

Histochemistry and cell biology·2012

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

Obesity and vascular risk.

¹Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium. roger.lijnen@med.kuleuven.be

Hamostaseologie

|January 20, 2009

Summary

Obesity increases the risk of blood clots by altering adipose tissue and impacting the fibrinolytic and matrix metalloproteinase (MMP) systems. Studies in obese mice confirm this heightened prothrombotic risk.

Area of Science:

Biomedical science
Cardiovascular research
Metabolic disorders

Background:

Obesity is a prevalent condition linked to increased vascular thrombotic complications.
Obesity development involves significant changes in adipose tissue, including adipogenesis, angiogenesis, and extracellular matrix remodeling.
The fibrinolytic and matrix metalloproteinase (MMP) systems are implicated in obesity-related adipose tissue modifications.

Purpose of the Study:

To investigate the role of fibrinolytic and MMP systems in obesity-induced adipose tissue changes.
To evaluate the prothrombotic risk associated with obesity using animal models.

Main Methods:

Utilized a nutritionally induced obesity model in transgenic mice.
Employed venous and arterial thrombosis models in obese mice.

More Related Videos

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Related Experiment Videos

Last Updated: Jun 26, 2026

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Pulse-Wave Velocity, Flow-Mediated Dilation, and Carotid Intima-Media Thickness to Assess Cardiovascular Risk in Population with Metabolic Syndrome

Published on: September 27, 2024

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Main Results:

Findings support the involvement of the plasminogen/plasmin and MMP systems in obesity-related adipose tissue processes.
Obese mice models confirmed an increased risk for both venous and arterial thrombosis.

Conclusions:

Obesity is associated with significant alterations in adipose tissue function.
The fibrinolytic and MMP systems play a role in obesity-related thrombotic risk.
Obesity models confirm a prothrombotic state.