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The toxicity, in vitro, of silicon carbide whiskers
G L Vaughan1, J Jordan, S Karr
1Zoology Department, University of Tennessee, Knoxville 37916.
Environmental Research
|October 1, 1991
Abstract:
To mouse cells in culture, SiC whiskers (SiCW) and asbestos are similarly cytotoxic, disrupting cell membranes and killing cells. Both shorten cell generation time, increase the rate of DNA synthesis, increase total cell DNA content, and cause a loss in growth control often associated with malignant cellular transformation. Within the narrow size range of materials examined, the amount of damage appeared to be more a function of the number of whiskers present than of their size. Silicon carbide whiskers, if mishandled, may pose a serious health hazard to humans.