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Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Label-free Single Molecule Detection Using Microtoroid Optical Resonators

Published on: December 29, 2015

Label-free detection with the resonant mirror biosensor.

Mohammed Zourob¹, Souna Elwary, Xudong Fan

¹Biosensors Division, Biophage Pharma, Montreal, QC, Canada.

Methods in Molecular Biology (Clifton, N.J.)

|January 20, 2009

Summary

The resonant mirror (RM) biosensor offers real-time, label-free monitoring of molecular interactions using evanescent fields. This versatile biosensing technology has broad applications in diagnostics and drug discovery.

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Biophysics

Background:

The resonant mirror (RM) biosensor is a waveguide-based instrument.
It utilizes the evanescent field to detect refractive index changes at the sensing surface.
This enables real-time, label-free monitoring of molecular interactions.

Purpose of the Study:

To review the principle of the resonant mirror biosensor.
To discuss recent advances in RM instrumentation and immobilization chemistries.
To highlight applications in various scientific and diagnostic fields.

Main Methods:

The RM biosensor operates by probing refractive index changes via an evanescent field.
It facilitates label-free detection of analyte-surface interactions.
The technology has been applied to study interactions of proteins, nucleic acids, cells, and receptors.

Main Results:

The RM biosensor allows for real-time monitoring of biomolecular interactions.
It has demonstrated versatility in studying diverse molecular moieties.
Applications span clinical diagnostics, homeland security, and pharmaceutical research.

Conclusions:

The resonant mirror biosensor is a powerful tool for label-free, real-time interaction analysis.
Its adaptable nature and broad applicability make it valuable across multiple scientific disciplines.
Continued advancements promise expanded utility in diagnostics and research.