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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Related Experiment Video

Updated: Jun 26, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

DNA analysis with a photo-diode array sensor.

Hideki Kambara¹, Guohua Zhou

¹Central Research Laboratory, Hitachi Ltd., Tokyo, Japan.

Methods in Molecular Biology (Clifton, N.J.)

|January 20, 2009

Summary

This summary is machine-generated.

A new, simple instrument enables easy DNA analysis using bioluminometry and a low-cost photo-diode array. This device offers a straightforward approach for diverse deoxyribonucleic acid (DNA) detection applications.

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Last Updated: Jun 26, 2026

Visual Detection of Multiple Nucleic Acids in a Capillary Array

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Published on: November 15, 2017

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Area of Science:

Biotechnology
Analytical Chemistry
Molecular Biology

Background:

Accurate deoxyribonucleic acid (DNA) analysis is crucial across various scientific disciplines.
Existing DNA analysis methods can be complex, time-consuming, or require expensive equipment.
There is a need for accessible and user-friendly DNA detection technologies.

Purpose of the Study:

To develop a simple and inexpensive instrument for performing various deoxyribonucleic acid (DNA) analyses.
To evaluate the characteristics and potential applications of this novel DNA analysis device.

Main Methods:

The instrument combines a bioluminometric assay with photo-detection.
An inexpensive photo-diode array serves as the core detection component.
The system is designed for straightforward operation and data acquisition.

Main Results:

The developed instrument demonstrates feasibility for deoxyribonucleic acid (DNA) analysis.
The combination of bioluminometry and photo-detection provides a sensitive detection method.
The device's characteristics are suitable for a range of DNA analysis tasks.

Conclusions:

A simple, cost-effective instrument for deoxyribonucleic acid (DNA) analysis has been successfully developed.
This device offers a practical solution for accessible DNA detection.
The instrument shows promise for various applications in biological research and diagnostics.