The contribution of cis-regulatory elements to head-to-head gene pairs' co-expression pattern

Transcription regulation is one of the most critical pipelines in biological process, in which cis-elements play the role as gene expression regulators. We attempt to deduce the principles underlying the co-expression of "head-to-head" gene pairs by analyzing activities or behaviors of the shared cis-elements. A network component analysis was performed to estimate the impact of cis-elements on gene promoters and their activities under different conditions. Our discoveries reveal how biological system uses those regulatory elements to control the expression pattern of "head-to-head" gene pairs and the whole transcription regulation system.