Related Experiment Video

Updated: Jun 26, 2026

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

Incremental prognostic value of cardiac single-photon emission computed tomography after nitrate administration in

Laura Evangelista1, Wanda Acampa, Mario Petretta

  • 1SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|January 20, 2009
PubMed

Insights

Nitrate myocardial viability assessment using technetium-99m sestamibi SPECT offers significant prognostic value in patients with ischemic left ventricular dysfunction. This imaging technique improves risk prediction beyond traditional clinical and baseline SPECT data.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diagnostic Imaging

Background:

  • Ischemic left ventricular (LV) dysfunction post-myocardial infarction (MI) requires accurate prognostic assessment.
  • Myocardial viability imaging aids in risk stratification and guiding revascularization decisions.

Purpose of the Study:

  • To evaluate the incremental prognostic value of nitrate-enhanced myocardial viability assessment using technetium-99m sestamibi single-photon emission computed tomography (SPECT).
  • To determine if nitrate SPECT improves risk prediction in patients with ischemic LV dysfunction.

Main Methods:

  • 164 patients with prior MI and LV dysfunction underwent two Tc-99m sestamibi SPECT studies (control and nitrate-enhanced).
  • Myocardial viability defined by preserved tracer uptake in dysfunctional segments.
  • Cardiac events (death, MI, late revascularization) were tracked over a mean of 30 months.

Main Results:

  • Baseline SPECT identified viability in 73% of patients.
  • Nitrate SPECT revealed viability in an additional 40% of patients initially deemed non-viable.
  • Event-free survival was significantly lower in patients with viability detected by nitrate SPECT (P < .01).

Conclusions:

  • Nitrate SPECT imaging provides incremental prognostic information in patients with ischemic LV dysfunction.
  • This adds value beyond clinical, functional, angiographic, and baseline SPECT data.
  • Nitrate SPECT enhances risk stratification for patients with previous myocardial infarction.
Abstract

More Related Videos

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Related Concept Videos

Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...