Related Experiment Video
Updated: Jun 26, 2026

Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets
Published on: March 12, 2019
The role of binding kinetics in therapeutically useful drug action
1Roche Palo Alto, CA 94304, USA. david.swinney@roche.com
Abstract:
Binding kinetics help define how a medicine will communicate with physiology to produce a desired therapeutic response. Clinical efficacy, duration of action, clinical differentiation and safety may all be influenced by binding kinetics. The optimization of binding kinetics can be used to maximize a drug's therapeutic index and thereby decrease drug attrition. The gap between basic scientific principles and the potential medical value of a drug is currently bridged by the use of empirical assays. The value of binding kinetics to drug discovery will be increased through an improved ability to identify optimal kinetic mechanisms and define kinetic structure activity relationships.
Related Concept Videos
Protein-Drug Binding: Mechanism and Kinetics
Various forces drive these interactions, including hydrogen bonds, hydrophobic interactions, ionic bonds, electrostatic interactions, and van der Waals forces. These bonds enable drugs to bind to specific sites on proteins,...
Principles of Drug Action
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
Pharmacokinetic–Pharmacodynamic Relationship: Problems
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
Physiological Pharmacokinetic Models: Assumption with Protein Binding
Drug Distribution: Tissue Binding
For...
