Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 26, 2026

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Serial-to-parallel interfaces for efficient sample transfer on microfluidic devices.

Zexi Zhuang¹, Stephen C Jacobson

¹Department of Chemistry, Indiana University, Bloomington, Indiana 47405-7102, USA.

Analytical Chemistry

|January 20, 2009

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficient septum formation is essential for chromosome segregation in <i>Bacillus subtilis</i> when SMC function is impaired.

bioRxiv : the preprint server for biology·2026

Same author

Constitutive, endogenous, fluorescent membrane reporters for dynamic cell cycle analysis in <i>Bacillus subtilis</i>.

bioRxiv : the preprint server for biology·2026

Same author

Polyanionic Sugars Drastically Affect Assembly of Human Papilloma Virus Virus-Like Particles.

ACS infectious diseases·2025

Same author

Effective Diameters of Virus-Like Particles Measured by Resistive-Pulse Sensing on In-Plane Nanopore Devices.

Analytical chemistry·2025

Same author

Speed Matters: Directed Assembly of Icosahedral HPV Virus-Like Particles.

Journal of the American Chemical Society·2025

Same author

Modular Anti-Counterfeit Tags Formed by Template-Assisted Self-Assembly of Plasmonic Nanocrystals and Authenticated by Machine Learning.

Advanced functional materials·2025

Same journal

The ACS at 150: The History of Analytical Chemistry Publications and a Century of Progress.

Analytical chemistry·2026

Same journal

Machine Learning-Enabled Image Analysis of Complex Chemical Mixtures: Synthetic Urine Droplets as a Test System.

Analytical chemistry·2026

Same journal

H<sub>2</sub>O<sub>2</sub>/Viscosity Tandem-Locked Fluorescent Probes Based on an In Situ Fluorophore Synthesis Strategy for Colitis Imaging and Diagnosis.

Analytical chemistry·2026

Same journal

TopoStitcher: A Geometric-Topological Structure-Guided Stitching Framework for Single-Molecule Localization Microscopy.

Analytical chemistry·2026

Same journal

Noninvasive SERS Immunosensing of Tyrosinase for Melanoma Monitoring via Microneedle Sampling Integrated with Satellite-Structured Bifunctional Nanozymes.

Analytical chemistry·2026

Same journal

Label-Free Electrochemical CRISPR Platform Gated by Allosteric Transcription Factors for Ultrasensitive Small-Molecule Detection.

Analytical chemistry·2026

See all related articles

Researchers developed novel serial-to-parallel interfaces for efficient microfluidic sample transfer. The gated valve design demonstrated superior performance and reproducibility for high-frequency sample injections.

Area of Science:

Microfluidics
Biotechnology
Chemical Engineering

Background:

Microfluidic devices enable precise control over small fluid volumes.
Efficient sample transfer from single to multiple channels is crucial for high-throughput analysis.
Existing methods often face challenges in speed, efficiency, and reproducibility.

Purpose of the Study:

To design and evaluate serial-to-parallel interfaces for rapid and efficient microfluidic sample transfer.
To compare the performance of three different interface designs.
To identify the optimal design for high-frequency sample injection into parallel channels.

Main Methods:

Three serial-to-parallel interface designs were fabricated and tested.
Routing channels were incorporated to direct sample flow and prevent leakage.

More Related Videos

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Related Experiment Videos

Last Updated: Jun 26, 2026

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

A Microfluidic Platform for Precision Small-volume Sample Processing and Its Use to Size Separate Biological Particles with an Acoustic Microdevice

Published on: November 23, 2015

Tee valves and gated valves were integrated into two designs to assist sample injection.

Injection times, frequencies, and area reproducibility were quantified.

Main Results:

Achieved injection times as short as 20 milliseconds and frequencies up to 10 Hz.
Demonstrated relative standard deviations less than 0.5% for injected area.
Transferred up to 50% of the sample efficiently with specific parameters (50 ms injection, 10 Hz frequency).
The interface incorporating a gated valve exhibited the highest performance and reproducibility.

Conclusions:

Novel serial-to-parallel interfaces enable rapid and efficient sample transfer in microfluidics.
Gated valve integration significantly enhances injection performance and reproducibility.
These interfaces are suitable for applications requiring high-throughput sample handling and analysis.