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Updated: Jun 26, 2026
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Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Published on: July 6, 2019
Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic
Matthias Meier1, Julia Kennedy-Darling, Se Hoon Choi
1Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
Angewandte Chemie (International Ed. in English)
|January 20, 2009
Abstract:
Small with control: For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug-based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume-limited samples, such as cerebrospinal fluid from mice.
