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Related Experiment Video

Updated: Jun 26, 2026

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
11:35

Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function

Published on: December 8, 2010

Tissue viability imaging: mapping skin erythema.

Hongbo Zhai1, Heidi P Chan, Sara Farahmand

  • 1Department of Dermatology, School of Medicine, University of California, San Francisco, CA, USA.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|January 21, 2009
PubMed
Summary
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Tissue Viability Imaging (TiVi) maps normal skin red blood cell concentration (RBC(conc)). This study quantifies RBC(conc) variations, establishing reference values crucial for assessing skin damage from various exposures.

Area of Science:

  • Bioengineering
  • Dermatology
  • Medical Imaging

Background:

  • Tissue Viability Imaging (TiVi) is an emerging technology for mapping skin erythema and blanching.
  • Understanding normal skin red blood cell concentration (RBC(conc)) variability is essential before applying TiVi to diseased or damaged skin.

Purpose of the Study:

  • To demonstrate TiVi's capability in mapping spatial and temporal variations of normal skin RBC(conc).
  • To evaluate RBC(conc) at the dorsal hand at rest and during post-occlusive hyperemia.

Main Methods:

  • Quantified short-term and day-to-day variations in skin RBC(conc) in four healthy volunteers at rest.
  • Recorded changes in skin RBC(conc) during post-occlusive hyperemia.

Main Results:

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  • Skin RBC(conc) was lower on the back of the hand and thumb base compared to finger nailfold regions.
  • Short-term variation (<2%) and day-to-day variation (5-10%) in RBC(conc) were observed.
  • Post-occlusive hyperemia induced up to a 60% increase in RBC(conc), remaining 18% above baseline after 30 min.

Conclusions:

  • Establishing reference values for healthy skin RBC(conc) is vital.
  • These values support the design of test procedures for assessing skin damage.
  • Applications include evaluating effects of vibration tools, chemical exposure, and peripheral vascular disease.