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The function of APC/CCdh1 in cell cycle and beyond

Min Li1, Pumin Zhang

  • 1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. pzhang@bcm.edu.

Cell Division
|January 21, 2009
PubMed

Insights

The anaphase promoting complex/cyclosome (APC/C) with its adaptor Cdh1 regulates mitosis and prevents premature cell cycle entry. This review summarizes APC/Cdh1 functions in cell cycle control and other cellular processes.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The anaphase promoting complex/cyclosome (APC/C) is a crucial E3 ubiquitin ligase essential for cell division.
  • APC/C utilizes adaptor proteins Cdc20 and Cdh1 to target substrates for degradation.
  • Both APCCdc20 and APCCdh1 play vital roles in mitotic progression.

Purpose of the Study:

  • To review the multifaceted functions of the APC/Cdh1 complex.
  • To explore APC/Cdh1's role in cell cycle regulation, including mitosis and G1/S transition.
  • To discuss APC/Cdh1's involvement in non-cell cycle-related cellular processes.

Main Methods:

  • Literature review of existing research on APC/C and its adaptors.
  • Analysis of studies investigating substrate specificity and regulation of APC/Cdh1.
  • Synthesis of findings on APC/Cdh1's impact on cell cycle progression and other cellular functions.

Main Results:

  • APCCdh1 mediates the ubiquitination and degradation of key mitotic regulators like cyclin B1, securin, and Plk1.
  • APCCdh1 prevents premature S phase entry by controlling mitotic cyclin levels in G1.
  • Evidence suggests APCCdh1 regulates cellular processes beyond cell cycle control.

Conclusions:

  • APC/Cdh1 is a critical regulator of mitosis and cell cycle progression.
  • APCCdh1's functions extend to diverse cellular processes, highlighting its broad biological significance.
  • Further research into APC/Cdh1 mechanisms will illuminate its role in both normal physiology and disease states.

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