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Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
Published on: May 3, 2018
The function of APC/CCdh1 in cell cycle and beyond.
1Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA. pzhang@bcm.edu.
Cell Division
|January 21, 2009
Summary
The anaphase promoting complex/cyclosome (APC/C) with its adaptor Cdh1 regulates mitosis and prevents premature cell cycle entry. This review summarizes APC/Cdh1 functions in cell cycle control and other cellular processes.
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- The anaphase promoting complex/cyclosome (APC/C) is a crucial E3 ubiquitin ligase essential for cell division.
- APC/C utilizes adaptor proteins Cdc20 and Cdh1 to target substrates for degradation.
- Both APCCdc20 and APCCdh1 play vital roles in mitotic progression.
Purpose of the Study:
- To review the multifaceted functions of the APC/Cdh1 complex.
- To explore APC/Cdh1's role in cell cycle regulation, including mitosis and G1/S transition.
- To discuss APC/Cdh1's involvement in non-cell cycle-related cellular processes.
Main Methods:
- Literature review of existing research on APC/C and its adaptors.
- Analysis of studies investigating substrate specificity and regulation of APC/Cdh1.
- Synthesis of findings on APC/Cdh1's impact on cell cycle progression and other cellular functions.
Main Results:
- APCCdh1 mediates the ubiquitination and degradation of key mitotic regulators like cyclin B1, securin, and Plk1.
- APCCdh1 prevents premature S phase entry by controlling mitotic cyclin levels in G1.
- Evidence suggests APCCdh1 regulates cellular processes beyond cell cycle control.
Conclusions:
- APC/Cdh1 is a critical regulator of mitosis and cell cycle progression.
- APCCdh1's functions extend to diverse cellular processes, highlighting its broad biological significance.
- Further research into APC/Cdh1 mechanisms will illuminate its role in both normal physiology and disease states.
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