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Cationic Nanoemulsion-Encapsulated Retinoic Acid as an Adjuvant to Promote OVA-Specific Systemic and Mucosal Responses

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Published on: February 23, 2024

Silica-based cationic bilayers as immunoadjuvants.

Nilton Lincopan¹, Mariana Ra Santana, Eliana Faquim-Mauro

¹Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Caixa Postal 26077, São Paulo-SP, Brazil.

BMC Biotechnology

|January 21, 2009

Summary

This summary is machine-generated.

Cationized silica particles with dioctadecyldimethylammonium bromide (DODAB) show improved antigen presentation and stability for vaccine design. These silica-based adjuvants outperform alum in cellular immune responses.

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Area of Science:

Nanotechnology
Immunology
Materials Science

Background:

Silica particles coated with dioctadecyldimethylammonium bromide (DODAB) bilayers were previously developed.
This study investigates their potential as adjuvants in vaccine design.

Purpose of the Study:

To evaluate the efficiency of silica/DODAB particles for antigen adsorption and presentation.
To compare their performance against alum as an adjuvant for vaccine development.

Main Methods:

Characterization of silica/DODAB particles using dynamic light scattering and zeta-potential analysis.
Determination of optimal conditions for antigen (BSA, 18 kDa-hsp) adsorption.
Assessment of in vivo cellular immune responses (DTH, cytokines) and humoral responses (IgG).

Main Results:

Stable, cationic bilayer-covered silica particles were formed using 0.05 mM DODAB.
Maximal antigen adsorption was achieved under specific conditions.
Silica/DODAB demonstrated superior cellular immune responses compared to alum and antigens alone.

Conclusions:

Cationized silica serves as a biocompatible, cost-effective, and easily prepared immunoadjuvant.
It offers enhanced colloid stability and cellular immune response compared to alum.
Effective antigen presentation is achieved using low, micromolar doses of DODAB.