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Alteration of diffusion tensor parameters in postmortem brain.

Elysa Widjaja1, Xingchang Wei, Logi Vidarsson

  • 1Diagnostic Imaging, Hospital for Sick Children, Toronto, Canada. Elysa.Widjaja@sickkids.ca

Magnetic Resonance Imaging
|January 21, 2009
PubMed
Summary
This summary is machine-generated.

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Postmortem diffusion MRI in pigs shows fractional anisotropy (FA) remains stable up to 72 hours after death. However, trace and eigenvalues decrease significantly within hours, limiting extrapolation from ex vivo to in vivo studies.

Area of Science:

  • Neuroimaging
  • Postmortem studies
  • Diffusion MRI

Background:

  • Human autopsies involve postmortem intervals (PMI) before tissue fixation.
  • Cooling cadavers retards autolysis during PMI.
  • Modeling PMI effects on diffusion indices is crucial for interpreting ex vivo MRI data.

Purpose of the Study:

  • To model the postmortem interval (PMI) in pigs.
  • To evaluate alterations in diffusion indices of the postmortem brain.
  • To assess the utility of diffusion MRI measurements within 3 days postmortem.

Main Methods:

  • Pigs were scanned using diffusion MRI before death and at multiple time points up to 72 hours postmortem.
  • Regions of interest were placed in white matter tracts (corpus callosum, internal capsule).

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  • Changes in fractional anisotropy (FA), trace, and eigenvalues (lambda major, medium, minor) were analyzed.

    • Main Results:

    • Fractional anisotropy (FA) showed a slight increase in the first 3 hours postmortem, then remained stable up to 72 hours.
    • Trace and eigenvalues demonstrated a marked decrease, particularly within the first 3 hours postmortem.
    • Significant alterations in diffusion indices occur within the first few hours postmortem.

    Conclusions:

    • Diffusion anisotropy measurements are potentially useful within 3 days postmortem.
    • Trace and eigenvalues decrease significantly in the early postmortem period.
    • Ex vivo diffusion MRI trace and eigenvalue data cannot be directly extrapolated to in vivo studies.