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Updated: Jun 26, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

Published on: May 20, 2020

Non-small-cell lung cancer dimensions: CT-pathological correlation and interobserver variation.

R E Macpherson¹, G S Higgins, J T Murchison

¹Departments of Radiology, New Royal Infirmary of Edinburgh, UK.

The British Journal of Radiology

|January 21, 2009

Summary

Accurate measurement of non-small cell lung cancer (NSCLC) is crucial for radiotherapy planning. This study found no specific CT window setting reliably improved tumour size accuracy or reduced radiologist variability.

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Area of Science:

Radiology
Oncology
Medical Imaging

Background:

Accurate tumor size measurement is vital for effective radiotherapy planning in non-small-cell lung cancer (NSCLC).
Computed Tomography (CT) is a key imaging modality for assessing tumor dimensions prior to treatment.

Purpose of the Study:

To determine the optimal CT window level setting for precise non-small-cell lung cancer measurement.
To enhance CT-based radiotherapy planning by identifying the most accurate measurement technique.

Main Methods:

Retrospective analysis of pre-operative CT scans from 27 NSCLC patients.
Comparison of radiological tumor measurements across four different CT window settings against pathological findings.
Assessment of interobserver variability between two independent radiologists.

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Last Updated: Jun 26, 2026

Pathological Analysis of Lung Metastasis Following Lateral Tail-Vein Injection of Tumor Cells

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Semi-automatic PD-L1 Characterization and Enumeration of Circulating Tumor Cells from Non-small Cell Lung Cancer Patients by Immunofluorescence

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Main Results:

A significant degree of interobserver variability was observed between radiologists.
Correlation between pathological and radiological tumor size measurements was poor.
No specific CT window setting demonstrated superiority in accurately assessing tumor dimensions.

Conclusions:

Current CT window settings do not consistently provide accurate measurements for non-small-cell lung cancer.
Radiotherapy planning based on CT measurements may be subject to significant variability.
Further research is needed to improve CT-based tumor sizing for NSCLC treatment optimization.