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Related Concept Videos

Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...

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A 3D System for Culturing Human Articular Chondrocytes in Synovial Fluid
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Published on: January 31, 2012

Injectable cartilage: using alginate and human chondrocytes.

Eric J Dobratz1, Soo Whan Kim, Andrew Voglewede

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Virginia, PO Box 800713, Charlottesville, VA 22908, USA.

Archives of Facial Plastic Surgery
|January 21, 2009
PubMed
Summary

Injectable engineered cartilage using human chondrocytes in alginate shows promise as a minimally invasive implant material for facial plastic surgery, maintaining shape for at least 38 weeks.

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Developing injectable materials for cartilage regeneration is crucial for minimally invasive reconstructive surgery.
  • Current implant materials often require complex surgical procedures.

Purpose of the Study:

  • To engineer injectable cartilage using human nasal chondrocytes within an alginate matrix.
  • To evaluate the feasibility of this material as a minimally invasive implant.

Main Methods:

  • Human nasal septal chondrocytes were encapsulated in alginate and injected percutaneously into nude mice.
  • The resulting engineered cartilage explants were analyzed from 14 to 38 weeks using gross, histological, immunohistochemical, and biochemical methods.

Main Results:

  • 93% of explants showed gross similarity to native cartilage.
  • 40% of explants were histologically similar to native cartilage, with 53% showing areas of fibrous differentiation.
  • Neocartilage stained positive for type II collagen, and hydroxyproline content was comparable to native cartilage in later-harvested or histologically superior samples.

Conclusions:

  • Injectable, autologous cartilage holds potential as an ideal implant for facial plastic surgery.
  • The alginate-chondrocyte composite can be molded and maintains size and shape for at least 38 weeks post-injection.