Peripheral precocious puberty: causes and current management
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1Section of Pediatric Endocrinology, Department of Pediatrics, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Ind., USA. eeugster@iupui.edu
Background:
Peripheral precocious puberty (PPP) results from sex steroid exposure by a process other than activation of the hypothalamic-pituitary-gonadal axis. It is much less common than central precocious puberty and may be congenital or acquired. Causes of PPP range from well-characterized genetic mutations to those conditions without a known etiology (idiopathic). Medical evaluation and treatment of affected children is guided by the presenting features and ultimate diagnosis.
Conclusions:
Carefully executed and collaborative multicenter investigations are essential to expand our knowledge of the underlying pathophysiology, optimal therapy and ultimate outcomes in children with PPP.
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