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An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
Published on: February 8, 2019
[Imaging techniques for giant cell arteritis. Ultrasound and MRI]
M Reinhard1, W A Schmidt, A Hetzel
1Neurologische Klinik, Universitätsklinikum Freiburg, Breisacher Str. 64, 79106 Freiburg. matthias.reinhard@uniklinik-freiburg.de
Abstract:
This article summarizes the examination technique, typical findings, interpretation and limitations of ultrasound diagnosis in patients with giant cell arteritis. Colour-coded sonography of the temporal artery has gained increasing attention. If experienced ultrasound examiners are available, diagnosis of giant cell arteritis in patients with a typical clinical constellation can be made based solely on sonographic findings, in particular by a hypoechogenic halo. The hitherto probably under-diagnosed large vessel variant of giant cell arteritis shows characteristic findings with a simple and quick ultrasound examination of the proximal arm arteries. High resolution MRI has been shown to be a promising technique for non-invasive imaging of giant cell arteritis. Mural inflammatory changes of the superficial temporal arteries can be depicted and the cranial involvement pattern can be readily assessed and in combination with MR angiography extracranial involvement can be determined within the same investigation. Aortitis is a feared complication of giant cell arteritis but can be detected and inflammatory stenoses of the aortic branch vessels can also be revealed. In the hands of an experienced operator ultrasonography can be regarded as the non-invasive imaging modality of first choice whereas MRI is more expensive and may not be as widely available. However, its imaging acquisition is standardized and is more observer-independent. Reading of the images is a routine task for a vascular radiologist and larger areas of the vasculature can be simultaneously assessed.
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