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The spectra of point mutations in vertebrate genomes

Guenter Albrecht-Buehler1

  • 1Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. g-buehler@northwestern.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|January 21, 2009
PubMed

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Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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