Related Experiment Video
Updated: Jun 26, 2026

Preparation of Hard Palm Seeds for Matrix-Assisted Laser Desorption/Ionization-Imaging Mass Spectrometry Analysis
Published on: June 30, 2023
The need for the establishment of a Brazilian Centre for the Validation of Alternative Methods (BraCVAM)
1Department of Pharmacology and Toxicology, National Institute of Quality Control in Health (INCQS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, RJ, Brazil. octavio.presgrave@incqs.fiocruz.br
Abstract:
Brazil has recently approved legislation for regulating experimental animal use. On the other hand, it is a requirement that the safety of many products on the market is controlled on the basis of animal testing. Some groups at official laboratories, universities and industries are studying alternative methods, but there is no approved mechanism for funding collaborative studies, nor is there an institution responsible for coordinating these studies. These shortcomings obstruct the development of these assays in Brazil. The creation of a Brazilian Centre for the Validation of Alternative Methods (BraCVAM) would facilitate the development and validation of tests in all the institutions working on alternative methods in Brazil, and could also offer support to other Latin American countries.
Related Concept Videos
Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
Bioequivalence studies: Biowaivers
Data Validation
Key parameters for method validation include:
Assessment of blood pressure in brachial artery(two-step method)
Development of Analytical Methods
Clinically Relevant Drug Product Specifications: Methods of Establishment