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Related Experiment Video

Updated: Jun 26, 2026

Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

Robust Comparison of Protein Levels Across Tissues and Throughout Development Using Standardized Quantitative Western Blotting

Published on: April 9, 2019

Developmental brain protein level changes in the C57BL/6J mouse.

Jae-Kyung Myung¹, Ki Shuk Shim, Lin Li

¹Department of Pediatrics, Medical University of Vienna, Vienna, Austria.

Journal of Proteome Research

|January 22, 2009

Summary

This summary is machine-generated.

This study identified developmentally regulated proteins in mouse brains, revealing changes in antioxidant, metabolic, and protein processing proteins during development. These findings highlight key molecular shifts in the brain from gestation to adulthood.

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Area of Science:

Neuroscience
Proteomics
Developmental Biology

Background:

Systematic searches for developmentally regulated proteins are limited.
Understanding protein expression changes during brain development is crucial.

Purpose of the Study:

To identify proteins that undergo developmental regulation in the mouse brain.
To analyze proteomic changes from prenatal to adult stages.

Main Methods:

Proteomic analysis of C57B/6J mouse brains at different developmental stages (gestation day 16, postnatal days 7, and 54-58).
Utilized a gel-based proteomic method with ion trap HCT for protein extraction and analysis.

Main Results:

Identified developmentally regulated proteins including antioxidants, cytoskeletal proteins, chaperones, metabolic enzymes, and protein synthesis/degradation machinery.
Observed regulation of sirtuin and a mitochondrial inner membrane protein.
Demonstrated significant proteomic alterations across different developmental time points.

Conclusions:

Mouse brain development involves dynamic regulation of a diverse set of proteins.
Findings provide a foundation for further research into the functional roles of these regulated proteins in brain maturation and function.