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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
Primary osteosarcoma of the breast.
Shigeki Murakami1, Hiroshi Isozaki, Tatsuo Shou
1Department of Surgery, Oomoto Hospital, Oomoto, Okayama, Japan. arztsm@ybb.ne.jp
Pathology International
|January 22, 2009
Summary
This case study details a rare primary pure osteosarcoma of the breast in a 59-year-old woman. The extraskeletal osteosarcoma was successfully treated with surgery, showing no recurrence after five years.
Area of Science:
- Oncology
- Pathology
Background:
- Primary osteosarcoma of the breast is an extremely rare malignant bone tumor.
- Extraskeletal osteosarcomas can arise in various soft tissues, but breast origin is exceptionally uncommon.
Observation:
- A 59-year-old woman presented with a left breast tumor exhibiting characteristic mammographic calcifications.
- Fine-needle aspiration cytology raised suspicion for malignancy.
- Histopathological examination revealed atypical osteoblasts, osteoclasts, and spindle cells, with significant bone formation.
Findings:
- Immunohistochemistry confirmed neoplastic osteoblastic cells positive for vimentin and negative for epithelial markers, suggesting epithelial origin.
- The tumor was diagnosed as primary extraskeletal osteosarcoma.
- The patient underwent partial resection and showed no recurrence at 5-year follow-up.
Implications:
- This case highlights the importance of considering rare diagnoses like extraskeletal osteosarcoma in breast lesions.
- Complete surgical resection appears to be an effective treatment strategy for this rare tumor.
- Further research into the pathogenesis and optimal management of primary breast osteosarcoma is warranted.
