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Hypoxia Alters miRNAs Levels Involved in Non-Mendelian Inheritance of Autism Spectrum Disorder in Mice

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Published on: July 11, 2025

Oxidative stress in developmental brain disorders.

Masaharu Hayashi¹

¹Department of Clinical Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan. mahayasi@tmin.ac.jp

Neuropathology : Official Journal of the Japanese Society of Neuropathology

|January 22, 2009

Summary

This summary is machine-generated.

Oxidative stress contributes to child-onset neurodegenerative disorders, including Cockayne syndrome and Lafora disease. Findings suggest antioxidant therapies may benefit patients with these developmental brain conditions.

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Area of Science:

Neuroscience
Biochemistry
Genetics

Background:

Oxidative stress is a known factor in adult neurological disorders.
Its role in child-onset neurodegenerative disorders requires further investigation.

Purpose of the Study:

To review findings on the involvement of oxidative stress in various child-onset neurodegenerative disorders.
To explore potential therapeutic targets for these conditions.

Main Methods:

Review of existing research and analysis of patient data.
Assessment of oxidative stress markers in brain tissue and urine samples.
Evaluation of specific oxidative damage products (lipids, proteins, DNA, nucleotides).

Main Results:

Increased oxidative stress markers were found in multiple child-onset neurodegenerative disorders.
Specific patterns of oxidative damage (e.g., lipid peroxidation, DNA damage) were identified in conditions like Cockayne syndrome, xeroderma pigmentosum, spinal muscular atrophy, subacute sclerosing panencephalitis, progressive myoclonic epilepsy, and Lafora disease.
Reduced copper/zinc superoxide dismutase (Cu/ZnSOD) expression was noted in xeroderma pigmentosum.

Conclusions:

Oxidative stress is implicated in the pathogenesis of developmental brain disorders.
Antioxidant agents show promise as a potential therapeutic strategy for these conditions.