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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Stroke: Introduction and Types01:29

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

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Related Experiment Video

Updated: Jun 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-stroke depression: can we predict its development from the acute stroke phase?

B Fuentes1, X Ortiz, B Sanjose

  • 1Department of Neurology, University Hospital La Paz, UAM, Madrid, Spain.

Acta Neurologica Scandinavica
|January 22, 2009
PubMed
Summary
This summary is machine-generated.

A high melancholy index on the Hamilton Depression Rating Scale (HDRS) in acute stroke patients predicts a greater risk of developing post-stroke depression (PSD). This finding aids in early identification of at-risk individuals.

Related Experiment Videos

Last Updated: Jun 26, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Neurology

Background:

  • Post-stroke depression (PSD) is a common complication affecting patient recovery.
  • Identifying predictive factors for PSD in the acute phase is crucial for timely intervention.

Purpose of the Study:

  • To identify predictive factors for post-stroke depression (PSD) during the acute phase of stroke.
  • To evaluate the utility of the melancholy index from the Hamilton Depression Rating Scale (HDRS) in predicting PSD.

Main Methods:

  • Prospective, observational cohort study of patients with acute cerebral infarction (CI).
  • Neurological and neuropsychological evaluations within 10 days of stroke onset and at 3-month follow-up.
  • DSM-IV criteria used for PSD diagnosis.

Main Results:

  • 17 out of 59 patients (28.8%) developed PSD at 3-month follow-up.
  • A higher melancholy index on the HDRS was significantly associated with increased PSD risk (OR 3.07).
  • Stroke severity and infarction location did not significantly influence PSD development.

Conclusions:

  • A melancholy index of 1.5 or greater on the HDRS can identify acute stroke patients at high risk for developing PSD.
  • The HDRS melancholy index serves as a valuable clinical tool for early PSD risk detection.