Related Experiment Video
Updated: Jun 26, 2026
Nerve Ultrasound Protocol to Detect Dysimmune Neuropathies
Published on: October 7, 2021
Sural nerve biopsy may predict future nerve dysfunction
S Thrainsdottir1, R A Malik, I Rosén
1Department of Clinical Sciences and Neurology, Lund University, Lund, Sweden. soleyth@landspitali.is
Objective:
Sural nerve pathology in peripheral neuropathy shows correlation with clinical findings and neurophysiological tests. The aim was to investigate progression of nerve dysfunction over time in relation to a baseline nerve biopsy.
Methods:
Baseline myelinated nerve fiber density (MNFD) was assessed in sural nerve biopsies from 10 men with type 2 diabetes, 10 with impaired and 10 with normal glucose tolerance. Nerve conduction and quantitative perception thresholds were estimated at baseline and follow-up (7-10 years later).
Results:
Subjects with low MNFD (< or = 4700 fibers/mm(2)) showed decline of peroneal amplitude (P < 0.02) and conduction velocity (P < 0.04), as well as median nerve sensory amplitude (P < 0.05) and motor conduction velocity (P < 0.04) from baseline to follow-up. In linear regression analyses, diabetes influenced decline of nerve conduction. MNFD correlated negatively with body mass index (r = -0.469; P < 0.02).
Conclusion:
Low MNFD may predict progression of neurophysiological dysfunction and links obesity to myelinated nerve fiber loss.
